Ask a doctor before use if you have - had heartburn over 3 months. This may be a sign of a more serious condition. Frequent wheezing, particularly with heartburn, unexplained weight loss, nausea or vomiting, stomach pain. Allergy alert: do not use if you are allergic to esomeprazole. Ask a doctor or pharmacist before use if you are taking warfarin, clopidogrel or cilostazol (blood-thinning medicines), prescription antifungal or anti-yeast medicines, digoxin (heart medicine), diazepam (anxiety medicine), tacrolimus or mycophenolate mofetil (immune system medicines), prescription antiretrovirals (medicines for hiv infection), methotrexate (arthritis medicine). If pregnant or breast-feeding, ask a health professional before use. Keep out of reach of children. In case of overdose, get medical help or contact a poison control center right away. (1-800-222-1222). Stop use and ask a doctor if - your heartburn continues or worsens, you need to take this product for more than 14 days, you need to take more than 1 course of treatment every 4 months, you get diarrhea. Do not use if you have: trouble or pain swallowing food, vomiting with blood, or bloody or black stools, heartburn with lightheadedness, sweating or dizziness, chest pain or shoulder pain with shortness of breath; Sweating; Pain spreading to arms, neck or shoulders; Or lightheadedness, frequent chest pain these may be signs of a serious condition. See your doctor.